The first clinical trial to test the effects of resveratrol — the plant compound plentiful in red wine and grapes — on humans has found that a small daily dose of a purified resveratrol supplement lowered blood pressure and improved a wide range of human health measures in a small group of obese men.
The study, conducted in the Netherlands and published this week in the journal Cell Metabolism, found that men taking 150 milligrams of resveratrol daily for 30 days looked for all the world as if they were either dieting successfully or were engaged in endurance training. (That dose is about the equivalent of the resveratrol in 100 glasses of red wine, so don’t pull that cork just yet.)
Without changing their diet or exercise habits, the mens’ metabolic function improved, evidence ofinflammation declined, fat deposits in their livers decreased and circulating triglyceride levels fell. While their bodies burned up the same amount of energy over a 24-hour period, their bodies’ resting and sleeping metabolic rate declined and their muscles’ use of fuel became more efficient — signs that they were using and storing calories more like athletes in training than obese couch potatoes.