Two Components of Red Meat Combined With Alteration in DNA Repair Increase Risk for Bladder Cancer

ScienceDaily (Oct. 17, 2012) — Two components of red meat — dietary protein and dietary iron — may combine to form powerful carcinogens, N-nitroso compounds, which increase risk for bladder cancer. Moreover, individuals with reduced ability to reverse the effects of N-nitroso compounds because of a genetic variation in their RAD52 gene could be at particularly high risk.

Research has shown that the processing and storage of meat increases amine concentrations. When these amines are in the presence of nitrites, they generate nitrosamines, which have carcinogenic properties. In addition, heme iron, found in red meat, has been shown to increase the formation of nitrosamines from amines.

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